• The JYNNEOS vaccine is FDA approved to prevent mpox disease in people aged 18 years and older. It is also available under FDA emergency use authorization (EUA) for people under aged 18 years.
• The JYNNEOS vaccine has been used to protect against clade II mpox disease since the 2022-2023 global mpox outbreak and is expected to protect against clade 1 mpox which is predominantly circulating in Africa, with sporadic cases detected in other countries including the United States.
• Persons at risk for mpox who have never had the disease are recommended to get vaccinated to protect against the disease.
• JYNNEOS is a two-dose vaccine that can decrease risk of symptomatic disease and severe complications of disease. The effectiveness of 1 dose is 75% and 2 doses is 86% against disease.
• Currently, there are no boosters or additional doses recommended.
• It takes 14 days after getting the second dose of JYNNEOS to get the best immune response against mpox. But even getting one dose can provide some protection.
• The vaccine can be given within 4 days of a possible exposure to mpox to help prevent infection. Additionally, giving it 4 to 14 days after exposure may still provide some protection or make the symptoms less severe.
• If someone already has mpox, the vaccine is not recommended as they will have protection from the infection.

If you have insurance, talk to your doctor or check with your local pharmacy to see what vaccines are offered. Most health insurances cover the cost of all recommended vaccines for eligible children and adults. Contact your health plan first to find out if they cover JYNNEOS and call ahead to make sure the JYNNEOS vaccine is available in advance of going to your vaccine provider.

LA County DPH Sexual Health Clinics offer JYNNEOS to individuals who are uninsured or underinsured. Call in advance to make an appointment and confirm vaccine availability. You may visit this site to access contact information, hours of operation, and appointment scheduling details: http://publichealth.lacounty.gov/chs/sexualhealthclinics/

If you are an uninsured or underinsured adult, you may be able to access low or no cost JYNNEOS vaccine at select locations that carry the vaccine, including federally qualified health centers. Some of these locations are listed on the local mpox vaccination referral sites list. You may also visit the Bavarian Nordic (JYNNEOS vaccine manufacturer) vaccine locator to search for vaccination sites near you.

Other programs or plans may cover the vaccine cost for people who are eligible, including:

• Pre-Exposure Prophylaxis Assistance Program (PrEP-AP)
  PrEP-AP helps Californians who are at risk for human immunodeficiency virus (HIV) infections get access to medical care and services to prevent HIV infection. JYNNEOS vaccine is a covered service for people enrolled in this program. See map of PrEP-AP sites here. For more information on who can apply, see CDPH PrEP Assistance Program: Eligibility Criteria.
  To apply for PrEP-AP:
  • Schedule an appointment at a certified PrEP-AP enrollment site near you, or
  • Contact the ADAP call center at (844) 421-7050, Monday-Friday, 8AM-5PM (excluding holidays)

• AIDS Drug Assistance Program (ADAP)
  ADAP helps ensure that Californians living with HIV and AIDS, who are uninsured or under-insured, have access to their prescribed medications. JYNNEOS vaccine is a covered service for people enrolled in this program. For more information on who can apply, see CDPH AIDS Drug Assistance Program (ADAP) Eligibility Criteria.
  To apply for ADAP:
  • Schedule an appointment at a certified ADAP enrollment site near you or
  • Contact the ADAP call center at (844) 421-7050, Monday-Friday, 8AM-5PM (excluding holidays)

Youth Under Age 18
If you are an uninsured or underinsured person aged 18 years or younger, you may be eligible to receive vaccines at no cost through the Vaccines for Children (VFC) Program if you are:

• Eligible for or are enrolled in Medi-Cal
• American Indian or Alaskan Native
• Uninsured (do not have health insurance)
• Underinsured (private health insurance does not cover the full cost of vaccines)

Consent for Minors

• At DPH Sexual Health Clinics that carry JYNNEOS vaccine, minors between the ages of 12-17 years may consent to receiving the vaccine. Please refer to the DPH justification for more information. If you are younger than aged 18 years and plan to receive the vaccine at a non-DPH site, please contact the vaccine provider to learn about their requirements for parental consent.
• Youth under 12 must be accompanied by a parent, legal guardian, or a designated responsible adult with a signed consent form naming them.

• Mpox Toolkit (LAC DPH) - includes social media materials, videos, and posters
• Mpox (CDC)
• Paying for Vaccines (LAC DPH)
• Flyers and signage (LAC DPH)

For information on mpox clinical presentation, testing, treatment, reporting, and clinical consultation, please visit the LA County Public Health Mpox Resource Page for providers.

CDC Clinical Resources

• Infection Prevention and Control in Healthcare Settings (CDC)
• Vaccine Administration Errors and Deviations (CDC)
• Strategies for Talking with Patients about Vaccination for Mpox (CDC)

JYNNEOS^TM Vaccine Information

• MMWR: Use of JYNNEOS (Smallpox and Mpox Vaccine, Live Nonreplicating) for Preexposure Vaccination of Persons at Risk for Occupational Exposure to Orthopoxviruses: Recommendations of the Advisory Committee on Immunization Practices — United States, 2022.
• FDA EUA Fact Sheet for Providers
• FDA EUA Fact Sheet for Patients and Caregivers
• JYNNEOS Package Insert
• JYNNEOS Vaccine Information Statement (VIS)